BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules
نویسندگان
چکیده
منابع مشابه
BIN1 Localizes the L-Type Calcium Channel to Cardiac T-Tubules
The BAR domain protein superfamily is involved in membrane invagination and endocytosis, but its role in organizing membrane proteins has not been explored. In particular, the membrane scaffolding protein BIN1 functions to initiate T-tubule genesis in skeletal muscle cells. Constitutive knockdown of BIN1 in mice is perinatal lethal, which is associated with an induced dilated hypertrophic cardi...
متن کاملDifferential modulation of the cardiac L- and T-type calcium channel currents by isoflurane.
BACKGROUND Volatile anesthetics exert their negative chronotropic and inotropic effects, in part by depressing the L- and T-type calcium channels. This study examines and compares the dose-dependent effects of isoflurane on atrial L- and T-type calcium currents (I(Ca,L) and I(Ca,T)) and ventricular I(Ca,L). METHODS Whole cell I(Ca) was recorded from enzymatically isolated guinea pig cardiomyo...
متن کاملCardiac L-type calcium channel (Cav1.2) associates with subunits
The cardiac voltage-gated Ca channel, Cav1.2, mediates excitation-contraction coupling in the heart. The molecular composition of the channel includes the pore-forming 1 subunit and auxiliary 2/ -1 and subunits. Ca channel subunits, of which there are 8 isoforms, consist of 4 transmembrane domains with intracellular Nand C-terminal ends. The 1 subunit was initially detected in the skeletal musc...
متن کاملgemini encodes a zebrafish L-type calcium channel that localizes at sensory hair cell ribbon synapses.
L-type Ca2+ channels (LTCCs) drive the bulk of voltage-gated Ca2+ entry in vertebrate inner ear hair cells (HCs) and are essential for mammalian auditory processing. LTCC currents have been implicated in neurotransmitter release at the HC afferent active zone, the ribbon synapse. It is likely that LTCCs play a direct role in vesicle fusion; however, the subcellular localization of the channels ...
متن کاملAntihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2.
The role of T-type Ca2+ channels for cardiovascular physiology, in particular blood pressure regulation, is controversial. Selective blockade of T-type Ca2+ channels in resistance arteries has been proposed to explain the effect of the antihypertensive drug mibefradil. In the present study, we used a third generation, time- and tissue-specific conditional knockout model of the L-type Ca2+ chann...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Biology
سال: 2010
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1000312